YURAK ISHEMIK KASALLIKLARI VA KOMORBID HOLATLARDA STATINLAR TERAPIYASI: ZAMONAVIY YONDASHUVLAR, SAMARADORLIK VA XAVFSIZLIK MEZONLARI.
Keywords:
Kalit so‘zlar. Statinlar, yurak ishemik kasalligi, ateroskleroz, LDL-xolesterin, dislipidemiya, komorbid holatlar, kardiovaskulyar xavf, miokard infarkti, insult, pleiotrop ta’sirlar, xavfsizlik, nojo‘ya ta’sirlar, lipid profil, HMG-CoA reduktaza., Keywords: Statins, coronary heart disease, atherosclerosis, LDL-cholesterol, dyslipidemia, comorbid conditions, cardiovascular risk, myocardial infarction, stroke, pleiotropic effects, safety, adverse effects, lipid profile, HMG-CoA reductase.Abstract
Annotatsiya. Ushbu maqolada yurak ishemik kasalligi va komorbid holatlarda statinlar terapiyasining samaradorligi va xavfsizligi ko‘rib chiqildi. Statinlarning LDL-xolesterinni kamaytirish, ateroskleroz jarayonini sekinlashtirish hamda yallig‘lanishga qarshi pleiotrop ta’sirlari asosiy klinik ahamiyatga ega ekani yoritildi. Qandli diabet, gipertoniya va buyrak kasalliklarida statinlarning kardioprotektiv foydasi alohida ta’kidlandi. Shuningdek, mushak tizimi va jigar funksiyasiga oid nojo‘ya ta’sirlar ham qisqacha tahlil qilindi. Umuman olganda, statinlar yurak-qon tomir kasalliklarining profilaktika va davosida yuqori samarali va nisbatan xavfsiz dori vositasi hisoblanadi.
Abstract. This article reviews the efficacy and safety of statin therapy in coronary heart disease and comorbid conditions. It highlights the main clinical importance of statins, including lowering LDL-cholesterol, slowing the progression of atherosclerosis, and their anti-inflammatory pleiotropic effects. The cardioprotective benefits of statins in diabetes mellitus, hypertension, and kidney diseases are also emphasized. In addition, adverse effects related to the muscular system and liver function are briefly analyzed. Overall, statins are considered highly effective and relatively safe drugs in the prevention and treatment of cardiovascular diseases.
