YURAK ISHEMIK KASALLIGI BO‘LGAN BEMORLARDA TIZIMLI YALLIG‘LANISH VA ADGEZIYA MOLEKULALARINING DIAGNOSTIK ROLINI KLINIK-LABORATOR BAHOLASH
Keywords:
Kalit so‘zlar: Yurak ishemik kasalligi, adgeziya molekulalari, sICAM-1, sE-selektin, LFA-1, immunoferment tahlilAbstract
Dolzarbligi. Yurak ishemik kasalligi (YIK) rivojlanishida qon tomir endoteliysining surunkali immun-yallig‘lanish jarayonlari va hujayralararo adgeziya mexanizmlari yetakchi o‘rin tutadi. Biroq, tizimli yallig‘lanish biomarkerlari va periferik qon leykotsitlarining tomir devoriga migratsiyasini ta'minlovchi oqsillarning o‘zaro korrelyatsiyasi mukammal baholanmagan.
References
1. To‘raqulov B.X., Abdumalikova F.B. Yurak ishemik kasalligining avj olishida yallig‘lanish sitokinlari va epigenetik biomarkerlarning o‘rni // O‘zbekiston Kardiologiya Jurnali. – 2026. – №1 (67). – B. 24–29.
2. Li Y., Zhang M., et al. Soluble adhesion molecules (sICAM-1, sVCAM-1) and endothelial dysfunction in stable coronary artery disease // Frontiers in Pharmacology. – 2026. – Vol. 17. – P. 112–118.
3. Muller C., Ross R. The role of E-selectin and P-selectin in plaque destabilization and acute coronary syndromes // Clinica Chimica Acta. – 2025. – Vol. 538. – P. 45–52.
4. Tojiddinov H.S. Yurak ishemik kasalligi va subklinik aterosklerozda endotelial biomarkerlarni kompleks baholash // Nazariy va klinik tibbiyot jurnali. – 2024. – №3. – B. 56–60.
